Hi, help us enhance your experience
Hi, help us enhance your experience
Hi, help us enhance your experience
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Dr KK Aggarwal 25 December 2019
Most vaccines are delivered by the intramuscular or subcutaneous routes. The intradermal route is only used for the administration of BCG and rabies vaccines.
There is now a renewed interest in intradermal vaccine delivery because the dermis and epidermis of human skin are rich in antigen-presenting cells, suggesting that delivery of vaccines to these layers, rather than to muscle or subcutaneous tissue, should be more efficient and induce protective immune responses with smaller amounts of vaccine antigen.
The recent PATH and WHO report reviewed more than 90 clinical trials of intradermal delivery with vaccines against 11 diseases.
For influenza and rabies vaccines, intradermal delivery of reduced doses resulted in equivalent immune responses to the standard dose delivered by the standard route. Data from trials with hepatitis B vaccine were encouraging and promising data was obtained with inactivated poliovirus, yellow fever and hepatitis A vaccines.
Take home messages
Dr KK Aggarwal
Padma Shri Awardee
President Confederation of Medical Associations in Asia and Oceania (CMAAO)
Group Editor-in-Chief IJCP Publications
President Heart Care Foundation of India
Past National President IMA
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